Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PR3 externalization depends on PLSCR1, but is independently of its serine-proteinase activity. Higher membrane PR3 expression on neutrophils after apoptosis without degranulation. Phospholipid scramblase 1 is involved in membrane PR3 expression during apoptosis-induced phospholipid redistribution between the two plasma membrane leaflets | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | proinflammatory role of membrane PR3 expression may involve interference with macrophage clearance of apoptotic neutrophils | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
RBL-2H3 rat mast-cell line stably transfected with PR3 or its inactive mutant S203A | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S203A | enzymatically inactive. PR3 externalization depends on PLSCR1, but is independently of its serine-proteinase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | less PR3 externalization in the presence of rPLSCR1 siRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
cytoplasm | PR3-phospholipid scramblase 1 colocolization | Homo sapiens | 5737 | - |
plasma membrane | PR3-phospholipid scramblase 1 colocolization | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | PR3-phospholipid scramblase 1 interaction | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Homo sapiens |
Wegener autoantigen | - |
Homo sapiens |